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The same trials are also the only window onto long-term safety: what are the implications of the elevated resting heart-rate in patients with heart failure or irregular heartbeats, let alone healthy individuals considering the longer term health implications of these drugs

This is one of the only drug classes that have been studied where that's the case, she says

In effect, the drug makes the body act like it is training for a marathon, leading to increased energy expenditure and faster metabolism of fat in the body

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